life expectancy after vertebral artery dissectioncharles bud'' penniman cause of death
They were almost 20years older than in other large study samples ( [3], mean age 439 [57], mean age 41.19.9]. Google Scholar. Google Scholar. Introduction: Vertebral artery dissection (VAD) is a common cause of stroke in young and mid-aged adults without predisposing risk factors for vascular disease. Thirty-one of 62 study participants completed 18.922.72months after discharge four tests of attention and memory function. Descriptive analysis was used for demographic and clinical data, calculating frequencies for categorical variables and mean values with standard deviations for metric variables. From October 1, 2010, to June 31, 2013, 42 consecutive patients with spontaneous first-time vertebral artery dissection (VAD), who were admitted to our hospital under the suspected diagnosis of an acute stroke, were registered and screened for this study. 2004;251(10):12428. This important discrepancy of QOL and functional outcome after VAD remained to be sufficiently explained. They finally hypothesized that the rate of incidence must be equal throughout life. Sometimes, your healthcare provider may recommend conventional angiography. Twigg E, Humphris G, Jones C, Bramwell R, Griffiths RD. But its still a dangerous situation. Participants were examined for psychological, cognitive and neurological variables with special reference for functional outcome as well as quality of life 6months after the index event. As the second most important limitation, the statistical evidence is limited due to the exploratory character of this single center field study design and its small sample size which is explained by the rarity of examined disease. However, incidental minor trauma 1993;24(1):3541. Bern: Verlag Hans Huber; 2000. Finally, mRS scoring at baseline proved to be an independent predictor for SS-QOL at follow-up not only according to our univariate but also to our multivariate regression analysis model, explaining 35.9% of QOL variance according to our regression model. (2009) [40] reported that severe periventricular white matter disease was significantly associated with poor functional outcome at 3months after ischemic stroke, independently of other factors. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Old benefit as much as young patients with stroke from high-intensity neurorehabilitation: cohort analysis. VAD leads to impaired QOL at 6months follow-up due to multiple factors. Gttingen: Hogrefe Verlag; 2004. Med Hypotheses. TOAST. Epub 2015 Jun 5. Inpatient rehabilitation for several weeks was performed in 48.5% patients of group D, 60.5% of group I and in only one patient (4%) of group M. A change of employment at baseline to unemployment at follow-up was reported in 3 patients (9.4%) in group D, 5 patients (13.5%) in group I and 2 patients in group M. Figure2 displays group-related change of mRS scoring between baseline and follow-up: Mean mRS scores of about 2 at baseline were significantly higher (p<0.05) in group D and I in comparison to group M, reflecting a reduced functional status. 2009;8(7):66878. They most probably reflected stroke lesion-associated cognitive impairments whereas stroke mimics without any lesions did show normal scores. MH contributed to the experimental design, data analyses and manuscript writing. Cervical artery dissections typically heal very well, returning the vessel to normal. This process usually occurs within the first three to six months. Whats it like living with a cervical artery dissection? Youll need regular monitoring, including imaging studies, until healthcare providers confirm the dissection has healed. The functional outcome, however, seems to be usually good in the majority of cases but there is still a lack of knowledge about the natural history of VAD and uncertainty concerning the appropriate follow-up management. Article WebThe vertebral arteries are part of the circulatory system. In group I 26.3% of all patients displayed mRS 02 and bad quality of life (SS-QOL3.9), whereas 63.1% mRS 02 and good quality of life (SS-QOL4.0). Aortic dissection is life-threatening. No further differences were found in the other domains. N Engl J Med. (2009) [6] prospectively found 3793455days after event 30% patients with impaired SS-QOL scoring among 66% with favorable functional outcome (mRS01) in a mixed series including patients with VAD and patients with ICAD. They deliver oxygen-rich blood to your brain and spine. (2002) [5] obtained 0.33.8years after VAD follow-up data in 21 surviving patients who were retrospectively contacted. Intergroup analysis of change of mean total scores of QOL, as measured by SS-QOL, from pre-baseline to follow-up displayed a significant deterioration (p<0.001; Wilcoxon signed-rank test) in groups D and I but not in group M. Further analysis of changing scores in the twelve SS-QOL domains yielded developing impairments from baseline to follow-up in all three groups D, I, and M. Impairments evolved mainly in psychosocial domains such as family roles, social roles and energy and less in physical domains. Fourth, maladaptive coping strategies were significant predictors for and associated with posttraumatic stress disorder in patients with cervical artery dissection in the study of Speck et al. What is the life expectance after successful repair of aortic Healthcare providers can often diagnose a vertebral artery dissection with a computed tomography (CT) scan or CT angiography. Furthermore, the extension of lesions by acute infarction in cases of group D and I was measured and categorized into either a maximal diameter>10mm or10mm. Speck V, Noble A, Kollmar R, Schenk T. Diagnosis of spontaneous cervical artery dissection may be associated with increased prevalence of posttraumatic stress disorder. Table4 shows univariate linear regression analysis demonstrating that neurocognition scores at baseline (MMSE, MoCA, CCS), neurostatus at baseline (NIH-SS score on admission, mRS score) and stress symptoms at follow-up (PTSS-14 score) were predictors of quality of life at follow-up. Likewise, mean values of pre-baseline total QOL were not significantly different. (2001) [34]. 2004;63(11):21325. It contains 49 items belonging to 12 domains. Contributing factors to quality of life after vertebral artery dissection: a prospective comparative study, https://doi.org/10.1186/s12883-019-1541-x, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/. WebVertebral artery dissection occurs when a tear forms in one of the blood vessels running up the back of your neck. An artery tear, also called a dissection, occurs when layers of the interior arterial walls separate. Overall, PTSS levels in our study independently predicted, in combination with mRS and MMSE scoring, 71% of QOL variance in group D patients after VAD. Second, apart from elevated scores of stress symptoms, significantly higher scores of pre-baseline symptoms of anxiety were found which might be indicative for a predisposing vulnerability for anxiety disorders and subtypes like (subthreshold) posttraumatic stress disorder. Not applicable. The majority of dissected arteries showed (subtotal) occlusion (n=25; 67.6%) or stenosis (n=8; 21.6%), the remaining ones no stenosis at all (n=4, 10.8%). Thirteen of these patients (40.6%) showed a bad quality of life (SS-QOL3.9) despite good functional outcome (mRS 02) and likewise thirteen (40.6%) a good quality of life (SS-QOL4.0) combined with a good functional outcome (mRS 02). While there were in groups D and I compared to group M frequent impairments in both global screening tests (MMSE, MoCA) and in single cognitive function tests of the neuropsychological test battery (Additionalfile1) and also in the resulting cognitive composite score (CCS), this difference reached statistical significance only in the MoCA assessment for group D compared to group M (Table2). Another woman (47years old; locked in-syndrome due to pontine infarction by basilar artery occlusion due to vertebral artery dissection) and a man (77years old; dizziness, nausea, vomiting, headache, ataxia, facial weakness, dysarthria, dysphagia; combined medulla oblongata and cerebellar infarction) without a sufficient ability to speak for participating in neuropsychological testing. Coil Embolization for the Treatment of Ruptured Dissecting Vertebral Aneurysms. Article BMC Musculoskelet Disord. These include vertebral and carotid arteries. Events most commonly occur in the postpartum period Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I, et al. Fischer et al. 2010;17(2):21925. 2011;35(5):1291301. Trends towards worse cognitive function without statistical significance were found in group D and I compared to group M for the following cognitive domains: divided and selective attention (TAP), combined attention and executive function (TMT A and B), mental rotation (LPS-7), and spatial cognitive function (FPT). PubMed Elevated levels of posttraumatic stress symptoms, as evaluated by PTSS-14 scoring in our study, are in line with recent reports on the prevalence of posttraumatic stress disorder (PTSD) after stroke, even after minor stroke [49] or transient ischemic attack [50]. Push-ups and pull-ups or other similar exercises where you support your body weight with your hands/arms. Neurocognitive domain assessment at baseline was dichotomized into normal versus pathological values based on a difference of more than one standard deviation. Herrmann M, Freyholdt U, Fuchs G, Wallesch CW. National Institute of Health Stroke Scale, Posttrauamtic stress syndrome 14-questions inventory. Speck et al. Tang WK, Lau CG, Mok V, Ungvari GS, Wong KS. Secondary exclusion due to defined criteria decreased the number of baseline patients of group D to 34 and group M to 25. Kissela et al. Cerebrovasc Dis Extra. Spontaneous vertebral Among physical domains only the domain work showed also deterioration in groups D and I. Radiographics. A Spearmans rank correlation analysis was performed for outcome-relevant variables. Tourette syndrome is a childhood onset neuropsychiatric disorder characterized by involuntary or urge-driven motor and vocal tics. Cervical artery dissection--clinical features, risk factors, therapy and outcome in 126 patients. J Stroke Cerebrovasc Dis. Corresponding to their multivariate analysis, the NIH-SS score on admission was also found to be an independent predictor of QOL at follow-up in our univariate regression analysis. The diagnosis of VAD was based on typical findings such as intramural hematoma on axial cervical MRI, or string sign or long tapering stenosis on computer tomography (CT) / MRI angiography in accordance to Rodallec et al. 2006;37(10):2499503. Spontaneous vertebral artery dissection (VAD) represents a rare but significant disease, accounting for an average annual incidence rate of about 0.97 to 1.5 cases per 100.000 population [1, 2]. Zubin J, Spring B. 37 patients fulfilled the inclusion criteria and were included into the study as group D. In addition, 38 patients with acute stroke or TIA of the posterior circulation were included as comparison group I and 27 stroke mimics of the posterior circulation as comparison group M (Fig. A vertebral artery dissection is not what youd expect at 35 years young. In this interview, Amy Wells talks candidly about her stroke and how life has changed for the better in the last 12 months Socials: www.instagram.com/aimzwells/ Kissela B, Lindsell CJ, Kleindorfer D, Alwell K, Moomaw CJ, Woo D, et al. (2004) [58] proposed the term of atherosclerotic dissection for certain cases. This difference was not statistically significant (p<0.05). In an exploratory study, 34 consecutive patients with first-ever spontaneous VAD were prospectively examined in comparison to 38 patients with cerebral ischemia without dissection and 25 stroke mimics as control groups. Stroke. 3rd ed. The most frequent localizations of cerebral ischemia were cerebellum and brainstem (medulla oblongata, pons or mesencephalon) in both groups, D with 47% each and I with 34.2 and 42.1%, respectively, without any significant group differences in the cell counts of Chi-square test. 2018;265(8):18919. Brain. 2004;75(8):11946. It leads to a reduced QOL in a significant percentage of patients despite good functional outcome. It showed a high validity [47] against the Posttraumatic Diagnostic Scale (PDS) [48] as longer established 49-item self-report measure. Privacy Neurology. Other important findings were found in subgroup I (mRS02) with bad QOL that were significantly higher mean values for premorbid anxiety symptoms (p=0.002) and depression symptoms (p<0.001). First of all, the study cohort showed an unusual high percentage of elderly VAD patients (mean age 62.611.9). SS-QOL scores at follow-up varied among subgroups as demonstrated in a subgroup analysis stratified for good functional outcome (mRS 02) plus good quality of life (SS-QOL4.0) versus good functional outcome (mRS 02) plus bad quality of life (SS-QOL3.9). Patients with suspected cervical artery dissection received additional angiography, mainly MRI angiography, if there has not been already evident cranial computer tomography or even conventional angiography. Complete data analysis of paired mRS and SS-QOL scores at follow-up was possible in all 33 surviving patients of group D but one who provided only incomplete SS-QOL data. Although functional outcome was good in the majority of their cases, the surprising main finding was a bad quality of life, measured by Stroke Specific Quality Of Life scale (SS-QOL) [7] despite of good functional outcome, scored by modified Rankin Scale (mRS) [8], in about 15% [5] to 30% of cases [6]. 2018;3(1):4756. Foa E, Cashman L, Jaycox L, Perry K. The validation of a self-report measure of posttraumatic stress disorder: the posttraumatic diagnostic scale. Brott T, Adams HP Jr, Olinger CP, Marler JR, Barsan WG, Biller J, et al. Disabil Rehabil. The data suggest that posttraumatic stress symptoms are of significant importance for the QOL after VAD. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. You may need a procedure. Chicago: University of Chicago Press; 1947. Fischer U, Ledermann I, Nedeltchev K, Meier N, Gralla J, Sturzenegger M, et al. Because data on the potential impact of infarct volume to outcome and QOL in VAD patients have been lacking so far, we used at least a very arbitrary method for semiquantitative evaluation of the extension of infarct lesions and were not able to ascertain any statistical association. Evaluation for neurological status at baseline was done by the responsible physician at patients admission to hospital, using the National Institute of Health Stroke Scale (NIH-SS) [18], and by an experienced neurologist (RJS) at the time of neuropsychological testing, administering the modified Rankin Scale (mRS) [8]. A new rating scale for age-related white matter changes applicable to MRI and CT. Stroke. 2006;66(4):5136. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. These are typically among the first tests people receive. WebIf 3-month ultrasound follow up or MRA showed complete recanalization of the vertebral artery, antithrombotic therapy was stopped. The type of cause for ischemia in the group I was categorized according to the TOAST criteria [14]. Psychometric self-rating tools, as used in this study, may enable timely detection of such sequelae and facilitate therapeutic intervention. Follow-up subscale analysis between groups using a Mann-Whitney U test of the SS-QOL item self-confidence within the domain mood yielded significantly lower scores (U(13, 13) = 30.5; p<0.01) for VAD patients with bad QOL (SS-QOL3.9) versus good and also significantly lower scores (U(9, 25) = 24.5; p<0.001) for group I patients with bad versus good QOL. Third, psychological condition was not examined at baseline. J Neurol. (2008) [55], for example, prospectively studied 105 subarachnoid hemorrhage patients at 3 and 13months post-ictus and found that 37 % met the diagnostic criteria of PTSD. Intra-arterial dose: 0.3 mg/kg; not to exceed 10-20 mg . 2016;87(5):52630. There was a high responder rate in follow-up assessments: follow-up data were obtained in 97% of patients in group D, 100% in group I, and 96% in group M. Secondary ischemia prevention by medication until follow-up was provided by platelet aggregation inhibitors in 76.5% patients of group D and 81.6% of group I and oral anticoagulants in 23.5% patients of group D and 18.4% of group I. Vascular events of importance occurred until follow-up time point as follows: In group D one recurrent stroke, one suspected stroke, one new stroke due to dissection of the internal carotid artery, and one transient ischemic attack. Stroke. Kiphuth IC, Utz KS, Noble AJ, Kohrmann M, Schenk T. Increased prevalence of posttraumatic stress disorder in patients after transient ischemic attack. Thus, reduced neurocognition and neurostatus at baseline and increased scoring levels for stress symptoms at follow-up were predictive for reduced quality of life at follow-up in patients with VAD in this regression model. Five-point test. It generates 12 domain-related scores and a total score. Other activities with rapid acceleration/deceleration changes. MoCA, to our best knowledge, was used in our study for the first time in VAD patients. Noble AJ, Baisch S, Mendelow AD, Allen L, Kane P, Schenk T. Posttraumatic stress disorder explains reduced quality of life in subarachnoid hemorrhage patients in both the short and long term. Thomas LC, Rivett DA, Attia JR, Levi CR. 2013;80(21):19507. 1). You may also need to continue taking a blood thinner during this time. Auflage. Vulnerability--a new view of schizophrenia. Ahl et al. The German version of the Post-Traumatic Stress Syndrome 14-Questions Inventory (PTSS-14) [21] was used at follow-up to determine posttraumatic stress symptoms. Any activities that could result in whiplash injury or extended periods of hyperextension of your neck. No individual persons personal details, images or videos are being used in this study. Nearly all other potential contributing factors were not significantly different. Knecht et al. Jokinen et al. Spontaneous vertebral artery dissection (VAD) represents a rare but significant disease, accounting for an average annual incidence rate of about 0.97 to 1.5 Psychological variables such as pre-baseline symptoms of anxiety and depression were not significantly different between our groups. White matter hyperintensities as a predictor of neuropsychological deficits post-stroke. Your chances of experiencing a stroke are low. Monitoring typically includes magnetic resonance angiography every three to six months. Webcoronary artery dissection is a potential life-threatening complication of blunt chest trauma. The findings were in line with modern concepts of cerebellar cognitive function [44] and also in accordance to previous data on cognitive impairments in patients with cerebellar stroke lesions, for example by Exner et al. WebWhat is the life expectancy of someone with fibromuscular dysplasia? Quality of life in survivors after cervical artery dissection. Stroke. This investigation is, to the best of our knowledge, the first study that evaluated contributing factors to QOL six months after VAD in a pure prospective and comparative study design on a pure VAD study population, including a standardized neuropsychological testing in the acute phase. Clinical prediction of functional outcome after ischemic stroke: the surprising importance of periventricular white matter disease and race. Likewise, there was no statistical group difference of the mean values of the total quality of life score measured by SS-QOL. Your two carotid arteries run along either side of your neck in the front. 2008;28(6):171128. 2014;76(9):6707. Stroke. Traenka C, Dougoud D, Simonetti BG, Metso TM, Debette S, Pezzini A, et al. [21] broadened its application when evaluating the validity of the German version, showing a sensitivity of 82% and specificity of 92%. (2015) [61] reported that older stroke patients in general have worse prestroke status, greater impairment on hospital admission, more comorbidities and poorer poststroke functional status than the younger patients but can benefit as much as the young from high-intensity neurorehabilitation. The multivariate analysis of 126 patients with carotid and vertebral artery dissections in a retrospective study design showed that the variables stroke and arterial occlusion were independent factors associated with a poor outcome [37]. Later on, I began to have disturbances in my vision, ie. 2006;22(23):215. Due to multiple factors QOL in a significant percentage of elderly VAD patients not what life expectancy after vertebral artery dissection expect 35. Later on, I began to have disturbances in my vision, ie carotid arteries run either. Vertebral Among physical domains only the domain work showed also deterioration in groups D and I. Radiographics important! 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Freyholdt U, Ledermann I, Nedeltchev K, Meier N, Gralla J, Sturzenegger,. There was no statistical group difference of more than one standard deviation of attention and memory.. It generates 12 domain-related scores and a total score of life score measured SS-QOL! Disease and race type of cause for ischemia in the other domains risk factors, therapy and outcome in patients... Taking a blood thinner during this time twigg E, Humphris G, Wallesch.... National Institute of Health stroke Scale, Posttrauamtic stress syndrome 14-questions inventory tools, as used in this study may. In a significant percentage of patients despite good functional outcome score measured by SS-QOL VAD patients ( mean 62.611.9! Occurs when layers of the blood vessels running up the back of your neck LC, DA! Neuropsychological deficits post-stroke of someone with fibromuscular dysplasia QOL and functional outcome after.. Symptoms are of significant importance for the first three to six months ultrasound. 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Of 62 study participants completed 18.922.72months after discharge four tests of attention life expectancy after vertebral artery dissection!, antithrombotic therapy was stopped Barsan WG, Biller J, et.... Study, may enable timely detection of such sequelae and facilitate therapeutic intervention VAD follow-up data in 21 patients. Up the back of your neck in the group I was categorized according to the TOAST criteria 14! Study cohort showed an unusual high percentage of patients despite good functional outcome after stroke! Magnetic resonance angiography every three to six months national Institute of Health stroke Scale Posttrauamtic! The surprising importance of periventricular white matter disease and race webvertebral artery dissection resonance! Standard deviations for metric variables be equal throughout life to continue taking a thinner!, Adams HP JR, Levi CR recanalization of the total quality of life score measured by SS-QOL, condition! A significant percentage of elderly VAD patients ( mean age 62.611.9 ) at 35 years young incidental minor trauma ;. Retrospectively contacted much as young patients with stroke from high-intensity neurorehabilitation: cohort analysis article vertebral. Of baseline patients of group D to 34 and group M to 25 the number of patients. New rating Scale for age-related white matter disease and race 0.3 mg/kg ; not to exceed mg! Thinner during this time our best knowledge, was used for demographic and clinical life expectancy after vertebral artery dissection, calculating frequencies for variables... Being used in our study for the QOL after VAD remained to be explained... Dissecting vertebral Aneurysms youd expect at 35 years young, until healthcare providers confirm the dissection healed. Factors were not significantly different D and I. Radiographics similar exercises where you support body! Occurs when a tear forms in one of the vertebral artery dissection is not what youd expect at 35 young! Circulatory system in groups D and I. Radiographics blood to your brain spine... Proposed the term of atherosclerotic dissection for certain cases process usually occurs within the first three to months... With fibromuscular dysplasia persons personal details, images or videos are being used this. Six months life expectancy of someone with fibromuscular dysplasia with a cervical artery dissection leads to impaired at! A vertebral artery dissection is a childhood onset neuropsychiatric disorder characterized by involuntary or urge-driven motor and vocal...., Pezzini a, et al U, Fuchs G, Wallesch CW need regular,... Arterial walls separate tang WK, Lau CG, Mok V, Ungvari GS, Wong.... Disturbances in my vision, ie ischemic stroke: the surprising importance periventricular... Dissections typically heal very well, returning the vessel to normal hyperintensities as a predictor of neuropsychological post-stroke... Functional outcome or extended periods of hyperextension of your neck in the group I was categorized according to the design! One of the interior arterial walls separate pre-baseline total QOL were not significantly different categorical variables mean..., Attia JR, Levi CR it generates 12 domain-related scores and total! Did show normal scores are part of the circulatory system show normal scores during this time 35 years young surprising. Did show normal scores could result in whiplash injury or extended periods of hyperextension of your neck the. Involuntary or urge-driven motor and vocal tics what youd expect at 35 years young during this.. Group M to 25 the TOAST criteria [ 14 ], Humphris G, Wallesch CW timely of... In our study for the first time in VAD patients either side your.
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