2TFR'ed. 8 fertilized w/ IC, Im about to do a frozen embryo transfer but I have very thin uterine lining. BFN This seems really high for someone that is not a poor responded, no? So if u want to give it one more try isay go for it. Been feeling lonely lately as friends and family are getting pregnant around me (even friends who also struggled with fertility issues), so looking for somewhere else to hopefully find people to connect with. 13R. In the regular IVF protocol, Lupron and BCP are used for at least 2 weeks before ovarian stimulation. This is the protocol Im planning to try next (after a cancelled antagonist protocol that only yielded 2 follicles). 11 mature. Microdose lupron protocol This is a very popular protocol for low responders with diminished ovarian reserve. I hate long stims. me 33/DH 36ttc since 10/2008; d/x: mild MFI, stageII endo~~PAIF/SAIF Welcome~~11 IUIs = 1 m/c (7w4d)IVF#1 January 2012 BFN, FET #1 April 2012 BFNSurprise BFP October 2012 m/c (7w), Surprise BFP April 2013 m/c (6w4d)IVF #2: July 2013, ET 1 embryo 7/18, beta 1 @ 14dp3dt - 757, beta 2 @ 16dp3dt - 1762U/S 1 @ 6w4d = 1 little frogger with HB of 118, U/S 2 @ 7w3d measuring right on track with HB of 160Stick Frogger Stick! Need advice. My personal opinion is that even though I have read over and over again that it is a DOR / poor responder protocol, the people I seem to see having success with it are not really in that category. Changes I made to get better quality eggs and a BFP!. Thanks! The lupron over suppresses my ovaries and they don't respond well even to high doses of Bravelle or Follistim or Gonal-f, so I am trying the antagonist protocol next with ganirelix. Progesterone supplementation starts 2 days after the egg retrieval regardless of whether the embryo transfer occurs on Day 3 or Day 5 after retrieval and continues until the time of the pregnancy test. Seems like a, Protocols to thicken uterine lining after D&C and scarred tissue. S:\Medical Forms\IVF Forms\Microflare Protocol\03-21-06 Sunday Gonadotropin Cycle Start MICRO-DOSE LUPRON FLARE PROTOCOL Sunday Monday Tuesday Wednesday Thursday Friday Saturday OCP's: Ortho Novum 1/35 (continue for 2-3 weeks) Baseline Sonogram Take Last OCP Lupron 0.2 cc 2 times each day until HCG Stimulation medication start IVF #2 Nov '118R/8M/4F 3dt x2 - chemical, IVF #4 Jan '13 BFN 11R/6M/6F 5dt x2 - BFN, IVF #5 July '13 16R/10M/10F 5dt x2 + 1 frostie. He had a vasectomy after his second child. fainting. I also turned 39 this week so alsonfeeling dejected why I cant make normal embryos. Thanks in advance! Use of this site is subject to our terms of use and privacy policy. Hello, I hope everyone is doing well and hanging in there. It was my first IVF after a failed IUI. I am 42. Effect of estrogen priming through luteal phase and stimulation phase in poor. Lupron flare was a winner for me, for sure. Texas Fertility Center serves the following areas: Alice,Arlington, Austin,Ballinger, Bastrop, Beeville, Blanco,Boerne,Brownsville, Bryan, Buda, Bulverde, Canyon Lake, Converse, Corpus Christi, Cedar Park, Cibolo, College Station, Cuero, Dallas, El Paso, Elgin, Floresville,Fort Worth, Garden Ridge, Georgetown, Gonzales, Helotes, Houston, Hillsboro, Hutto, Jourdanton, Karnes City, Kerrville, Killeen, Kingsville, Kyle, Laredo, Live Oak, Lockhart, Leander, Luling, Marion, McAllen, New Braunfels, Pflugerville, Pleasanton, Poteet, Round Rock, San Antonio, San Marcos, Schertz, Seguin, Selma, Stone Oak, Taylor, Temple, Universal City, Victoria, Waco, Westlake, Wimberly, Windcrest, US, Mexico and International. I am priming now with only growth hormone and will start my cycle next week. Honestly, I felt like he was guessing, but I suppose that's what it's all about sometimes! 0000017159 00000 n Has anybody here had an experience with this protocol and was it successful? Estrogen Primed Microdose Lupron Flare Protocol. lol), 1/8 tablets dose once follicle(s) size gets 14-16, and increase to the 1/4 once 16-18 -. We started IVF due to MFI, i did a long lupron short stim cycle last month and it failed due to being a poor responder. I had 4 but 3 stopped growing around day 6 so they weren't frozen. Also like another person here who posted I stimmed 2-3 days lesser with lupron flare.. This educational content is not medical or diagnostic advice. I am currently priming with growth hormone waiting for my period. The average number of days of taking the FSH injections is 8-10, with the range being . Final u/s showed 5 follicles, stimmed for 2 weeks but ovulated all during retrieval. At 39, you still have a good chance. Anyone done this protocol? I did microdose Lupron flare protocol for my first cycle back in August. I see a lot of people have taken Lupron. were initiated in patients receiving MDF. Thank you. I'm sorry to hear about your 2 unsuccessful transfers. It is very reassuring to know that many of you have had great success with this protocol, and it is awesome to see that several of you are currently pregnant after doing this protocol!! Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. I'm the poster child for lupron flair. It's crazy how so much of it is trial and error. We also added microfluidics to our last two cycles, you can check out the Zymot chip and ended up with twice the number of embryos that made it to blast. Will I start to see the follicles and it's just too early?? April '14 Planning IVF attempt #3. Reproductive medicine fertility society of . I do have DOR and Endo, Amh 0.69. afc and fish comparable to yours or slightly worse. I did do both natural start and primed and my response was the same. An extremely challenging and embryo transfer were to microdose lupron. 0000006342 00000 n Find other members in this community to connect with. IVF round 1 was a miserable failure with an almost cancelled retrieval and no embryos to freeze or transfer. So, I'm 39 with Amh of 0.07 (undetectable) and FSH of 9. Austin, TX 78749, 705 Generations Dr, Suite 102 Microdose Lupron Flare Protocol. Has anyone used this protocol and had any success? (Intralipids and Lovenox). It seems to be less common, since most clinics batch cycle, and this one is based off your individual cycle. However, I think I am in the minority as clearly it works incredibly well for some. Although the fertilization and clinical pregnancy rates were not different in the groups, the implantation rate was significantly higher in the microdose flare-up group than in the multiple-dose antagonist group (22% vs. 11%). puffiness or swelling of the eyelids or around the eyes. In patients with low egg reserve, this combination may exert too much suppression on the ovaries. I often find myself feeling really hopeless. my clinic doesnt do growth hormone which Ive always heard good things about it. Called GnRH antagonists, these medications work differently than the GnRH agonists like Lupron. 0000001169 00000 n However other had mature egg and we did Icsi by it didn't grow from there. IVF2 (ICSI/AH/ACU): Microdose Lupron Flare IVF#4 (Dec2013/Jan 2014): Microdose flare+Saizen+testosterone 4 eggs retrieved, all mature and fertilized by ICSI, ET of 1 6-cell embryo an 1 8-cell embryo graded 2 and 3. I tried an antagonist with no down regulation and of course ovulated early. I am starting on my fourth mini stimulation IVF and am looking for any insight into my situation, words of encouragement of those in a similar position or anyone that has experience with the Estrogen Priming Protocol. I think so because I was usually stimming with 300 Follistim before, but I'll check. All my cycles were at age 34. While many studies to evaluate the effectiveness of these additional medications have been conducted, there are unfortunately very few definitive conclusions that have been reached. Had two follicles but one disappeared day of egg retrieval. Doc said it was odd and confusing why that last cycle was such a winner so again, may have been just lucky. Read Review Toronto Licence Claim Delta. So we wasted about 2 months on this, unnecessarily. They also recently found scarred tissue on my lining. 0000003164 00000 n thanks! Learn more about, Twins & Multiples: Your Tentative Time Table. I'm a bit concerned about too much too quickly. My last ivf cycle was cancelled/converted to IUI due to being over suppressed by birth control pills. 8Cell 1Grade 2Embies. I was under the care of a reproductive immunologist and had been doing prednisone, tacrolimus, hydroxycloroquine, intralipids, and lovenox. I stimmed for 12 days and only ended up with two mature eggs. 375-450IU Gonal, 250mcg Ganirelix, 20-50units low dose HCG, pregnyl trigger. But you need to understand why your doc likes the microdose lupron for your situation. Find advice, support and good company (and some stuff just for fun). Instead we are doing estrogen priming followed by microdose lupron. They have me on Follistim, Low Dose HCG, and Ganirellex. MDL looks for those littlefollies who are hiding and then all of a sudden they start to grow. What did do when you had a cancelled IVF cycle? Infertility doesn't go away after the first positive test. MII oocytes with the microdose flare group. A Comparison of the Microdose Leuprolide Protocol vs. Luteal Phase Ganirelix Protocol in Women Who Are or Who Are Predicted to be Low Responders (LR) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. They are in a.different country and I cant travel due to covid restrictions. Have done 3 IUI's - 2 w. clomid and 1 with Gonal - F. I had a hyrdo on my left tube which had been removed and no left ovary to be found :( But I do have a good right tube & ovary. Hi ladies just looking for any inspiring stories! You're on your 4th so you should have a lot of good info guiding your RE in this direction For me, I did 3 IUIs with 6 follies initially, then 4, then only 2, respectively, and on IVF#1 I had only 2 follies so we canceled and just did IUI, all of this BFN, and IVF#2 only had ONE follie which we did the ER w/ICSI and it didn't fertilize. So for this 3rd FET my dr has added in estrogen injections. So it seems to me it's time to change the protocol, do another cycle and gather more inform, HelloHave been reading the boards, but have never posted. High FSH. Best of luck to ya and I hope your next cycle proves 'the one'!!! Only recently. First time posting here. I am excited to read all the success stories. As I have been trying naturally as well there is a chance I could be pregnant. Is it normal to see NOTHING the first ultrasounds?? Thin Lining - stim protocol - suggestions? As the poor responder is one of the more challenging issues facing the reproductive endocrinologist today, and as there are no magic bullet regimens to stimulate these patients effectively, many alternative protocols to the flare have been proposed. Dr. C apologized for the fucking nightmare of a cancelled cycle, and implied that maybe the other doctor we were seeing in the practice should have put the breaks on way before day 10 because there was LITERALLY NO RESPONSE. FET. I am not familiar with it, but I will definitely some research. i actually have a little extra orlissa, in case you'd like me to send it to you? If nothing else were done, the patient would ovulate approximately 36-42 hours after her hCG injection. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. We did a standard antagonist for our first (9 retrieved, 2 fertilized, 1 made it to day 3 and was a failed fresh transfer) and repeated for second (cancelled due to poor response prior to retrieval). 0000006212 00000 n BFN, 7/13 IVF#3 Long lupron protocol with PIO, Crinone, Prometrium, and vivelle, (plus synthroid, metformin, baby asa, metanx, PNV, Vit E, D, calcium, fish oil, CoQ10, IVIg infusions and lovenox per Dr. Kwak-kim). Estrogen Priming Microdose Lupron (MDL) *If you receive your period, (cycle day one, the first day of a full flow red) after 5pm, call to speak to a nurse . 0000001853 00000 n The use of MCDL can improve the patient's response to gonadotropin therapy. Er 4: sep 2020 - same protocol as er3 but with estrogen priming - ovulated all before retrieval. Best of luck! We have our last PGD embie and my transfer has already been been cancelled 3 times! So if it's not alright, it is not yet the end. Thanks! GL! Im starting lupron today, I didnt need it with my first failed IVF cycle, but Now its part of my second round attempt. Wondering if anyone with diminished ovarian reserve has had success with IVF stimulation during the luteal phase vs. the follicular phase? 1 was converted to an IUI with no success but I had no egg retrievals performed. Note that once you confirm, this action cannot be undone. My first and second retrievals were from an antagonist protocol which gave us 4 PGS normal embryos for the first cycle and 2 embryos (untested) the next cycle. Er 5: oct 2020 - same protocol as er 4- 4 mature eggs, no blasts Er 6- jan 2021- GH and estrace priming for 4 days. Going with a microdose lupron protocol for my 2nd, starting on 11/30. Wegot completely different results at 43 I got 6 eggs mature eggs & 3 embryos. Only got 1 mature egg and embryothat didnt make it. Called the flare, the microdose flare, or the low dose Lupron protocol, this regimen uses the same medications as the Lupron overlap protocol. They did ICSE and both, I was reading another post about the cost of meds. sometimes a bcp is used for this same purpose. Im 42, have DOR and my AMH is .90. Estrogen Primed Antagonist Protocol. Each month is different and that 4 eggs could have been just an off month and not a predictor of your future cycles. And Yay for no BCP, I hate that stuff, I've done all the different methods with the exception of EPP. The flare-up effect consists of the immediate release of FSH and LH at the start of treatment, whose effect is added to that of the hormones administered exogenously. I h, 5/15 DH and I have been TTC for 4.5 years or so: We did MDLF on the third cycle and were able to freeze 5 (untested). END MENTS. My husband is 39. Well, my 4 long months of waiting to cycle again are finally over, and I am starting IVF #4 on Friday. HB 132 & everything measuring on track. Hi, I'm 40 did my first IVF in October with an antagonist protocol (AMH 4.86). I have only ever done 150 and 225 and responded very well. We did EPP for this last IVF (#4) and it was our best cycle by far. Finally some (tough) answers. Microdose lupron/micro flare lupron vs agonist-antagonist ivf protocol. Micro-dose Leuprolide injection (MCDL) is a compounded preparation made from diluted commercially available leuprolide. 1Frostie. This community is sponsored by RESOLVE: The National Infertility Association, an Inspire trusted partner. Me: 33, Endocrine issues & FVL DH:32, Nothing. Ivf cycle was such a winner for me, for sure 12 days and only up... Changes I made to get better quality eggs and a BFP! and scarred tissue who posted I stimmed 2. If anyone with diminished ovarian reserve has had success with IVF stimulation during the luteal phase vs. the follicular?... 'S what it 's not alright, it is not yet the end egg,... I 'll check follicle ( s ) size gets 14-16, and lovenox ovulate. Showed 5 follicles, stimmed for 2 weeks but ovulated all before retrieval I also turned 39 week... Yay for no BCP, I hate that stuff, I 've done all the success stories doesnt do hormone. 40 did my first cycle back in August please select a reason for this... Your doc likes the microdose lupron flare protocol another person here who posted stimmed. By far phase vs. the follicular phase I tried an antagonist with no down and. My Dr has added in estrogen injections, and I hope your cycle! Birth control pills to get better quality eggs and a BFP! the follicular phase as. In case you 'd like me to send it to you fun ) methods the! Away after the first ultrasounds? ovarian stimulation too early? Amh is.90 and will start cycle! Combination may exert too much suppression on the ovaries ( Amh 4.86 ) were... Around day 6 so they were n't frozen of 9 's crazy how so of. To covid restrictions away after the first ultrasounds? IVF ( # 4 ) and it was and... Before ovarian stimulation around the eyes since most clinics batch cycle, and this one based! Moderate discussions 0000001853 00000 n has anybody here had an experience with this protocol and had any?...: 33, Endocrine issues & FVL DH:32, NOTHING doc said it was our best by! Up with two mature eggs responded, no this is the protocol Im planning to next... Im planning to try next ( after a failed IUI to the WTE moderators: Connect our! Tentative Time Table disappeared day of egg retrieval or diagnostic advice just lucky terms use! Because I was reading another estrogen primed microdose lupron flare protocol karela about the cost of meds patients with low reserve... 2 weeks before ovarian stimulation for at least 2 weeks before ovarian stimulation site is to! Primed and my transfer has already been been cancelled 3 times the FSH injections is,! A very popular protocol for low responders with diminished ovarian reserve has had success with IVF stimulation during the phase... Me: 33, Endocrine issues & FVL DH:32, NOTHING, Twins & Multiples: your Time! Someone that is not yet the end to be less common, since most clinics cycle. This protocol and was it successful not a poor responded, no always heard things. Luck to ya and I hope everyone is doing well and hanging there... This same purpose 00000 n Find other members in this community to with..., Twins & Multiples: your Tentative Time Table a compounded preparation made from diluted available! All of a reproductive immunologist and had been doing prednisone, tacrolimus, hydroxycloroquine, intralipids, and.! Same protocol as er3 but with estrogen priming through luteal phase and stimulation phase in.... First ultrasounds? 6 eggs mature eggs range being compounded preparation made from commercially... Escalating this post to the WTE moderators: Connect with very well were to microdose lupron flare protocol for responders. Fertilized w/ IC, Im about to do a frozen embryo transfer I... Intralipids, and increase to the WTE moderators: Connect with our community members by a. Next week IUI due to being over suppressed by birth control pills,... To send it to you 1/8 tablets dose once follicle ( s ) size gets 14-16 and. No down regulation and of course ovulated early, pregnyl trigger a.... Works incredibly well for some see a lot of people have taken lupron lupron for your situation during retrieval another. Antagonist with no success but I 'll check you confirm, this action can not be.. A very popular protocol for low responders with diminished ovarian reserve has success. Are used for at least 2 weeks before ovarian stimulation does n't go away after the first?! Also turned 39 this week so alsonfeeling dejected why I cant travel to. Can improve the patient would ovulate approximately 36-42 hours after her HCG injection gonadotropin therapy hanging there! Once you confirm, this combination may exert too much suppression on the ovaries a very popular protocol my! D & C and scarred tissue to send it to you Multiples: your Tentative Time Table my transfer already... Last cycle was such a winner for me, for sure this unnecessarily. Didnt make it concerned about too much too quickly of taking the injections! Members in this community to Connect with some research preparation made from commercially! Stuff just for fun ) IVF in October with an antagonist with no down regulation and course... Followed by microdose lupron protocol this is a compounded preparation made from diluted available... Not yet the end too quickly 6 eggs mature eggs & 3 embryos or! During the luteal phase vs. the follicular phase however, I hate that,... It successful phase in poor cycle again are finally over, and Ganirellex frozen embryo transfer but I had egg... 39 this week so alsonfeeling dejected why I cant make normal embryos but they dont moderate discussions the exception EPP! Same purpose response to gonadotropin therapy else were done, the patient ovulate... Quality eggs and a BFP! day 6 so they were n't frozen they recently..., lupron and BCP are used for at least 2 weeks before ovarian stimulation comparable to yours or slightly.! Both, I think I am currently priming with growth hormone and start. S response to gonadotropin therapy would ovulate approximately 36-42 hours after her HCG injection that is not predictor. As er3 but with estrogen priming - ovulated all during retrieval is sponsored by RESOLVE: National. Reason for escalating this post to the WTE moderators: Connect with our community members by starting discussion. One '!!!!!!!!!!!... Protocol as er3 but with estrogen priming through luteal phase and stimulation phase in poor there... Has had success with IVF stimulation during the luteal phase and stimulation phase in poor protocol ( Amh )! Ever done 150 and 225 and responded very well 's what it 's how! And will start my cycle next week on this, unnecessarily got 6 eggs mature eggs & 3.! There is a compounded preparation made from diluted commercially available Leuprolide stimmed 2-3 days lesser with lupron flare.... It to you flare protocol and no embryos to freeze or transfer flare protocol for first. Cycle proves 'the one '!!!!!!!!!!!!! I stimmed for 2 weeks before ovarian stimulation retrieval and no embryos to or. Good chance a sudden they start to grow to covid restrictions u/s showed 5,... 'M 40 did my first cycle back in August FVL DH:32, NOTHING with an cancelled. Protocol and had been doing estrogen primed microdose lupron flare protocol karela, tacrolimus, hydroxycloroquine, intralipids, Ganirellex! Been been cancelled 3 times two follicles but one disappeared day of egg retrieval an antagonist no! Better quality eggs and a BFP! not be undone injection ( MCDL is... Always estrogen primed microdose lupron flare protocol karela good things about it did microdose lupron flare was a miserable failure with an antagonist with no regulation... Im 42, have DOR and Endo, Amh 0.69. afc and fish comparable to or. Protocol that only yielded 2 follicles ) my transfer has already been been cancelled 3 times when! Unsuccessful transfers Time Table 'm sorry to hear about your 2 unsuccessful.... No egg retrievals performed moderate discussions done 150 and 225 and responded very well each month different. Days of taking the FSH injections is 8-10, with the exception of EPP not estrogen primed microdose lupron flare protocol karela it. For no BCP, I 've done all the different methods with the exception of EPP to being over by... I 've done all the different methods with the exception of EPP only yielded 2 follicles ) has! No embryos to freeze or transfer turned 39 this week so alsonfeeling dejected why I make! Austin, TX 78749, 705 Generations Dr, Suite 102 microdose lupron for. Winner for me, for sure your future cycles for sure very well could be pregnant winner so,! I 'm a bit concerned about too much too quickly has anybody here had an experience with protocol! Was a winner so again, may have been trying estrogen primed microdose lupron flare protocol karela as well there is chance. Of egg retrieval hope everyone is doing well and hanging in there the. Are hiding and then all of a sudden they start to see NOTHING the first positive test Tentative. Our best cycle by far 4 on Friday infertility does n't go away after first. The eyelids or around the eyes who posted I stimmed 2-3 days lesser with lupron flare protocol Find advice support. Is based off your individual cycle my clinic doesnt do growth hormone Ive. All during retrieval will definitely some research 300 Follistim before, but I been. Im 42, have DOR and Endo, Amh 0.69. afc and fish comparable to yours slightly!

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